Article

Antagonism of Propofol Anesthesia by Alkyl-fluorobenzene Derivatives

2024-01-11

Abstract excerpt

<title>Abstract</title> <p>Despite their frequent use across many clinical settings, general anesthetics are medications with lethal side effects and no reversal agents. A fluorinated analogue of propofol has previously been shown to antagonize propofol anesthesia in tadpoles and zebrafish, but little further investigation of this class of molecules as anesthetic antagonists has been conducted. A 13-member librar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f403ea40-8eab-5826-bbf6-570a8c98fd4a
DOI: 10.21203/rs.3.rs-3846123/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antagonism of Propofol Anesthesia by Alkyl-fluorobenzene DerivativesDOI 10.21203/rs.3.rs-3846123/v1Read

Zebrafish: A Pharmacogenetic Model for Anesthesia.Semantic proximity Read

Inhibitory ligand-gated ion channels as substrates for general anesthetic actions.Semantic proximity Read

Inhibition of Ligand-Gated TRPA1 by General Anesthetics.Semantic proximity Read

Developmental toxicity of fluconazole and 1,2,4-triazole in non-target aquatic vertebratesSemantic proximity Read

Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy.Semantic proximity Read

Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1)Semantic proximity Read

Efficacy and safety of ciprofol vs. propofol for maintenance and induction of general anesthesia: A meta-analysis of 463 patientsSemantic proximity Read

Adverse Outcomes Following Exposure to Perfluorooctanesulfonamide (PFOSA) in Larval Zebrafish (<em>Danio rerio</em>): A Neurotoxic and Behavioral PerspectiveSemantic proximity Read

Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X7 Receptor Antagonist.Semantic proximity Read

1-Azinyl-1’-Alkenylferrocenes with Anticholinesterase, Antioxidant, and Antiaggregating Activities as Multifunctional Agents for Potential Treatment of Alzheimer’s DiseaseSemantic proximity Read

Effects of two different compounds on seizure suppression using the zebrafish PTZ-seizure modelSemantic proximity Read

Actions of fluorinated alkanols on GABA(A) receptors: relevance to theories of narcosis.Semantic proximity Read