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Article

Fluconazole inhibits hERG K(+) channel by direct block and disruption of protein trafficking.

European journal of pharmacology - 10 Jan 2011

Han Shengna, Zhang Yu, Chen Qiu, Duan Yanyan, Zheng Tenghao, Hu Xiangjie, Zhang Zhao, Zhang Lirong

Abstract excerpt

Fluconazole, a commonly used azole antifungal drug, can induce QT prolongation, which may lead to Torsades de Pointes and sudden death. To investigate the arrhythmogenic side effects of fluconazole, we studied the effect of fluconazole on human ether-a-go-go-related gene (hERG) K(+) channels (wil...

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Share to Dose-Response Relationship, Drug
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20951697
DOI: 10.1016/j.ejphar.2010.10.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20951697-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fluconazole inhibits hERG K(+) channel by direct block and disruption of protein trafficking.PMID 20951697Read ↗

Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome.Semantic proximity Read ↗

Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656.Semantic proximity Read ↗

Pharmacological corrections of the mutant hERG channels by posaconazole.Semantic proximity Read ↗

Blockage of hERG current and the disruption of trafficking as induced by roxithromycin.Semantic proximity Read ↗

Clenbuterol Attenuates hERG Channel by Promoting the Mature Channel Degradation.Semantic proximity Read ↗

Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.Semantic proximity Read ↗

F463L increases the potential of dofetilide on human ether-a-go-go-related gene (hERG) channels.Semantic proximity Read ↗

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652.Semantic proximity Read ↗

Lidoflazine is a high affinity blocker of the HERG K(+)channel.Semantic proximity Read ↗

Propofol inhibits hERG K+ channels and enhances the inhibition effects on its mutations in HEK293 cells.Semantic proximity Read ↗

Blockade of the human ether-a-go-go-related gene potassium channel by ketanserin.Semantic proximity Read ↗

Molecular Determinants for the High-Affinity Blockade of Human Ether-à-go-go-Related Gene K + Channel by Tolterodine.Semantic proximity Read ↗

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