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Article

Investigating the impact of hepatitis B virus surface gene polymorphism on antigenicity using ex vivo phenotyping.

The Journal of general virology - 1 Nov 2012

Ijaz Samreen, Szypulska Renata, Andrews Nick, Tedder Richard S

Abstract excerpt

The hepatitis B virus (HBV) surface antigen (HBsAg) is a complex protein, and understanding accurately the impact of amino acid changes on the antigenicity of the immunodominant a determinant must take this complexity into consideration. Epitope mapping with four mAbs was used to phenotype HBsAg directly from patients' sera to investigate the effect of mutations in their native genetic backbone. The expected mAb...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22855781
DOI: 10.1099/vir.0.044305-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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