Multiple epitopes of hepatitis B virus surface antigen targeted by human plasma-derived immunoglobulins coincide with clinically observed escape mutations.

Abstract excerpt

Hepatitis B immune globulin (HBIG) is a human plasma-derived immunoglobulin G concentrate that contains a high titer of neutralizing antibodies (anti-HBs) to the hepatitis B virus (HBV) surface antigen (HBsAg). HBIG is known to be highly effective in treating HBV infections, however, a more systematic characterization of the antibody binding sites on HBsAg and their correlation with emerging "escape" mutations in...

Topics

• Epitopes
• Hepatitis B
• Hepatitis B Antibodies
• Hepatitis B Surface Antigens
• Hepatitis B virus
• Humans
• Immunoglobulins
• Mutation
• Peptide Library