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Article

A covering method for detecting genetic associations between rare variants and common phenotypes.

PLoS computational biology - 14 Oct 2010

Bhatia Gaurav, Bansal Vikas, Harismendy Olivier, Schork Nicholas J, Topol Eric J, Frazer Kelly, Bafna Vineet

Abstract excerpt

Genome wide association (GWA) studies, which test for association between common genetic markers and a disease phenotype, have shown varying degrees of success. While many factors could potentially confound GWA studies, we focus on the possibility that multiple, rare variants (RVs) may act in concert to influence disease etiology. Here, we describe an algorithm for RV analysis, RareCover. The algorithm combines a...

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PMID: 20976246
DOI: 10.1371/journal.pcbi.1000954
PMCID: PMC2954823

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FAAH
MGLL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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