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Article

Human genetic variation altering anthrax toxin sensitivity.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2012

Martchenko Mikhail, Candille Sophie I, Tang Hua, Cohen Stanley N

Abstract excerpt

The outcome of exposure to infectious microbes or their toxins is influenced by both microbial and host genes. Some host genes encode defense mechanisms, whereas others assist pathogen functions. Genomic analyses have associated host gene mutations with altered infectious disease susceptibility, but evidence for causality is limited. Here we demonstrate that human genetic variation affecting capillary...

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Share to Antigens, Bacterial
Share to Bacterial Toxins
Share to Endocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genetics, Population

Share to Membrane Proteins

Share to Receptors, Peptide

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Identifiers

PMID: 22315420
DOI: 10.1073/pnas.1121006109
PMCID: PMC3286947

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