Article
(19)F nuclear magnetic resonance and crystallographic studies of 5-fluorotryptophan-labeled anthrax protective antigen and effects of the receptor on stability.
Biochemistry - 4 Feb 2014
Chadegani Fatemeh, Lovell Scott, Mullangi Vennela, Miyagi Masaru, Battaile Kevin P, Bann James G
Abstract excerpt
The anthrax protective antigen (PA) is an 83 kDa protein that is one of three protein components of the anthrax toxin, an AB toxin secreted by Bacillus anthracis. PA is capable of undergoing several structural changes, including oligomerization to either a heptameric or octameric structure called the prepore, and at acidic pH a major conformational change to form a membrane-spanning pore. To follow these...
Topics
- Antigens, Bacterial
- Bacillus anthracis
- Bacterial Toxins
- Crystallography, X-Ray
- Fluorescent Dyes
- Humans
- Hydrogen-Ion Concentration
- Models, Molecular
- Molecular Weight
- Mutation