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Article

Mechanisms of SecM-mediated stalling in the ribosome.

Biophysical journal - 18 Jul 2012

Gumbart James, Schreiner Eduard, Wilson Daniel N, Beckmann Roland, Schulten Klaus

Abstract excerpt

Nascent-peptide modulation of translation is a common regulatory mechanism of gene expression. In this mechanism, while the nascent peptide is still in the exit tunnel of the ribosome, it induces translational pausing, thereby controlling the expression of downstream genes. One example is SecM, which inhibits peptide-bond formation in the ribosome's peptidyl transferase center (PTC) during its own translation,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22853911
DOI: 10.1016/j.bpj.2012.06.005
PMCID: PMC3400775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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