Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel.

Molecular cell - 24 Apr 2009

Yap Mee-Ngan, Bernstein Harris D

Abstract excerpt

The recognition of a C-terminal motif in E. coli SecM ((150)FXXXXWIXXXXGIRAGP(166)) inside the ribosome tunnel causes translation arrest, but the mechanism of recognition is unknown. Whereas single mutations in this motif impair recognition, we demonstrate that new arrest-inducing peptides can be created through remodeling of the SecM C terminus. We found that R163 is indispensable but that flanking residues that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Escherichia coli
Share to Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Biosynthesis

Share to Protein Interaction Mapping

Share to Ribosomal Proteins

Share to Ribosomes

Share to Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 19394297
DOI: 10.1016/j.molcel.2009.04.002
PMCID: PMC2704006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel.PMID 19394297Read ↗

Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.Semantic proximity Read ↗

The ribosomal exit tunnel functions as a discriminating gate.Semantic proximity Read ↗

Identification of a hyperactive variant of the SecM motif involved in ribosomal arrest.Semantic proximity Read ↗

Nascent SecM chain interacts with outer ribosomal surface to stabilize translation arrest.Semantic proximity Read ↗

Identification of a SecM segment required for export-coupled release from elongation arrest.Semantic proximity Read ↗

The conformation of a nascent polypeptide inside the ribosome tunnel affects protein targeting and protein folding.Semantic proximity Read ↗

Mechanisms of SecM-mediated stalling in the ribosome.Semantic proximity Read ↗

Translation arrest of SecM is essential for the basal and regulated expression of SecA.Semantic proximity Read ↗

Identification and characterization of a translation arrest motif in VemP by systematic mutational analysis.Semantic proximity Read ↗

Exploration of the arrest peptide sequence space reveals arrest-enhanced variants.Semantic proximity Read ↗

Regional discrimination and propagation of local rearrangements along the ribosomal exit tunnel.Semantic proximity Read ↗

Signal peptide mimicry primes Sec61 for client-selective inhibitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.