Critical regions of secM that control its translation and secretion and promote secretion-specific secA regulation.

Abstract excerpt

SecA is an essential ATP-driven motor protein that binds to presecretory or membrane proteins and the translocon and promotes the translocation or membrane integration of these proteins. secA is subject to a protein secretion-specific form of regulation, whereby its translation is elevated during secretion-limiting conditions. A novel mechanism that promotes this regulation involves translational pausing within...

Topics

• 3' Untranslated Regions
• Adenosine Triphosphatases
• Amino Acid Sequence
• Bacterial Proteins
• Enterobacteriaceae
• Escherichia coli Proteins
• Gene Expression Regulation, Bacterial
• Genes, Bacterial
• Membrane Transport Proteins
• Molecular Sequence Data
• Mutation
• Protein Biosynthesis
• Protein Sorting Signals