Article
Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P.
Molecular cell - 2 Nov 2017
Huter Paul, Arenz Stefan, Bock Lars V, Graf Michael, Frister Jan Ole, Heuer Andre, Peil Lauri, Starosta Agata L, Wohlgemuth Ingo, Peske Frank, Nováček Jiří, Berninghausen Otto, Grubmüller Helmut, Tenson Tanel, Beckmann Roland, Rodnina Marina V, Vaiana Andrea C, Wilson Daniel N
Abstract excerpt
Ribosomes synthesizing proteins containing consecutive proline residues become stalled and require rescue via the action of uniquely modified translation elongation factors, EF-P in bacteria, or archaeal/eukaryotic a/eIF5A. To date, no structures exist of EF-P or eIF5A in complex with translating ribosomes stalled at polyproline stretches, and thus structural insight into how EF-P/eIF5A rescue these arrested...
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