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Article

The ribosomal exit tunnel functions as a discriminating gate.

Cell - 8 Mar 2002

Nakatogawa Hitoshi, Ito Koreaki

Abstract excerpt

Translation of SecM stalls unless its N-terminal part is "pulled" by the protein export machinery. Here we show that the sequence motif FXXXXWIXXXXGIRAGP that includes a specific arrest point (Pro) causes elongation arrest within the ribosome. Mutations that bypass the elongation arrest were isol...

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Identifiers

PMID: 11893334
DOI: 10.1016/s0092-8674(02)00649-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11893334-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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The ribosomal exit tunnel functions as a discriminating gate.PMID 11893334Read ↗

Identification of a SecM segment required for export-coupled release from elongation arrest.Semantic proximity Read ↗

The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel.Semantic proximity Read ↗

Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.Semantic proximity Read ↗

Nascent SecM chain interacts with outer ribosomal surface to stabilize translation arrest.Semantic proximity Read ↗

Identification and characterization of a translation arrest motif in VemP by systematic mutational analysis.Semantic proximity Read ↗

Translation arrest of SecM is essential for the basal and regulated expression of SecA.Semantic proximity Read ↗

Identification of a hyperactive variant of the SecM motif involved in ribosomal arrest.Semantic proximity Read ↗

Search for translation arrest peptides encoded upstream of genes for components of protein localization pathways.Semantic proximity Read ↗

Exploration of the arrest peptide sequence space reveals arrest-enhanced variants.Semantic proximity Read ↗

Single rRNA helices bind independently to the protein-conducting channel SecYEG.Semantic proximity Read ↗

A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mechanisms of SecM-mediated stalling in the ribosome.Semantic proximity Read ↗

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