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Article

Identification of a SecM segment required for export-coupled release from elongation arrest.

FEBS letters - 25 Aug 2014

Nakamori Kenta, Chiba Shinobu, Ito Koreaki

Abstract excerpt

SecM in Escherichia coli has two functionally crucial regions. The arrest motif near the C-terminus interacts with the ribosomal exit tunnel to arrest its own translational elongation. The signal sequence at the N-terminus directs the SecM nascent polypeptide to the Sec-mediated export pathway to...

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Identifiers

PMID: 24967850
DOI: 10.1016/j.febslet.2014.06.038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24967850-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a SecM segment required for export-coupled release from elongation arrest.PMID 24967850Read ↗

Nascent SecM chain interacts with outer ribosomal surface to stabilize translation arrest.Semantic proximity Read ↗

Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.Semantic proximity Read ↗

The ribosomal exit tunnel functions as a discriminating gate.Semantic proximity Read ↗

Translation arrest of SecM is essential for the basal and regulated expression of SecA.Semantic proximity Read ↗

The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel.Semantic proximity Read ↗

Critical regions of secM that control its translation and secretion and promote secretion-specific secA regulation.Semantic proximity Read ↗

Identification and characterization of a translation arrest motif in VemP by systematic mutational analysis.Semantic proximity Read ↗

Identification of a hyperactive variant of the SecM motif involved in ribosomal arrest.Semantic proximity Read ↗

Mechanisms of SecM-mediated stalling in the ribosome.Semantic proximity Read ↗

A SecE mutation that modulates SecY-SecE translocase assembly, identified as a specific suppressor of SecY defects.Semantic proximity Read ↗

Search for translation arrest peptides encoded upstream of genes for components of protein localization pathways.Semantic proximity Read ↗

Exploration of the arrest peptide sequence space reveals arrest-enhanced variants.Semantic proximity Read ↗

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