Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a hyperactive variant of the SecM motif involved in ribosomal arrest.

Current microbiology - 1 Jan 2012

Ha Hye-Jeong, Yeom Ji-Hyun, Song Woo-Seok, Jeon Che Ok, Hahn Yoonsoo, Lee Kangseok

Abstract excerpt

Recent studies in several organisms have shown that certain nascent sticky peptides stall in the ribosome during their own translation. Amino acid sequences present at the C-terminal part of Escherichia coli SecM ((150)FSTPVWISQAQGIRAGP(166)) have a well-characterized role in ribosome stalling. To investigate the determinants of the SecM motif responsible for ribosome stalling, we performed a genetic screen for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Variation
Share to Amino Acid Motifs
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli Proteins

Share to Molecular Sequence Data

Share to Protein Biosynthesis

Share to Ribosomes

Share to Transcription Factors

Source

Identifiers

PMID: 21971705
DOI: 10.1007/s00284-011-0027-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a hyperactive variant of the SecM motif involved in ribosomal arrest.PMID 21971705Read ↗

The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel.Semantic proximity Read ↗

Translation arrest of SecM is essential for the basal and regulated expression of SecA.Semantic proximity Read ↗

The ribosomal exit tunnel functions as a discriminating gate.Semantic proximity Read ↗

Critical regions of secM that control its translation and secretion and promote secretion-specific secA regulation.Semantic proximity Read ↗

Nascent SecM chain interacts with outer ribosomal surface to stabilize translation arrest.Semantic proximity Read ↗

Identification of a SecM segment required for export-coupled release from elongation arrest.Semantic proximity Read ↗

Mechanisms of SecM-mediated stalling in the ribosome.Semantic proximity Read ↗

Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.Semantic proximity Read ↗

Identification and characterization of a translation arrest motif in VemP by systematic mutational analysis.Semantic proximity Read ↗

Effects on translation pausing of alterations in protein and RNA components of the ribosome exit tunnel.Semantic proximity Read ↗

A SecE mutation that modulates SecY-SecE translocase assembly, identified as a specific suppressor of SecY defects.Semantic proximity Read ↗

Exploration of the arrest peptide sequence space reveals arrest-enhanced variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.