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Targeting Hedgehog — a Cancer Stem Cell Pathway

9 Jun 2010

Abstract excerpt

The Hedgehog (Hh) pathway has been implicated in a wide variety of human tumors, and early clinical trials with pathway antagonists have validated Hh signaling as a bona fide anticancer target. Despite these encouraging results, several issues surrounding the basic biology of the Hh pathway in human cancers remain unclear. These include the influence of specific oncogenic events on Hh signal transduction, the...

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PMID: 20530699
DOI: 10.1158/1078-0432.ccr-09-2846

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