Article
Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis.
PloS one - 1 Jan 2013
Rossi Silvia, Studer Valeria, Moscatelli Alessandro, Motta Caterina, Coghe Giancarlo, Fenu Giuseppe, Caillier Stacy, Buttari Fabio, Mori Francesco, Barbieri Francesca, Castelli Maura, De Chiara Valentina, Monteleone Fabrizia, Mancino Raffaele, Bernardi Giorgio, Baranzini Sergio E, Marrosu Maria G, Oksenberg Jorge R, Centonze Diego
Abstract excerpt
Synaptic transmission and plasticity mediated by NMDA receptors (NMDARs) could modulate the severity of multiple sclerosis (MS). Here the role of NMDARs in MS was first explored in 691 subjects carrying specific allelic variants of the NR1 subunit gene or of the NR2B subunit gene of this glutamate receptor. The analysis was replicated for significant SNPs in an independent sample of 1548 MS subjects. The C allele...
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