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Article

Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients.

Scientific reports - 15 Jan 2021

Smets Ide, Goris An, Vandebergh Marijne, Demeestere Jelle, Sunaert Stefan, Dupont Patrick, Dubois Bénédicte

Abstract excerpt

Magnetization transfer ratio (MTR) and brain volumetric imaging are (semi-)quantitative MRI markers capturing demyelination, axonal degeneration and/or inflammation. However, factors shaping variation in these traits are largely unknown. In this study, we collected a longitudinal cohort of 33 multiple sclerosis (MS) patients and extended it cross-sectionally to 213. We measured MTR in lesions, normal-appearing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33452402
DOI: 10.1038/s41598-021-81035-8
PMCID: PMC7811013

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