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Article

Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis.

Brain : a journal of neurology - 1 Sept 2010

Baranzini Sergio E, Srinivasan Radhika, Khankhanian Pouya, Okuda Darin T, Nelson Sarah J, Matthews Paul M, Hauser Stephen L, Oksenberg Jorge R, Pelletier Daniel

Abstract excerpt

Glutamate is the main excitatory neurotransmitter in the mammalian brain. Appropriate transmission of nerve impulses through glutamatergic synapses is required throughout the brain and forms the basis of many processes including learning and memory. However, abnormally high levels of extracellular brain glutamate can lead to neuroaxonal cell death. We have previously reported elevated glutamate levels in the...

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Identifiers

PMID: 20802204
DOI: 10.1093/brain/awq192
PMCID: PMC2929334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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