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Article

Interaction of water with the G-quadruplex loop contributes to the binding energy of G-quadruplex to protein.

Molecular bioSystems - 1 Oct 2012

Nagatoishi Satoru, Sugimoto Naoki

Abstract excerpt

Unlike DNA duplexes that release water upon interaction with protein, the binding of DNA G-quadruplex of the thrombin-binding aptamer (TBA) to thrombin takes up water. Here, to reveal the mechanism of water uptake, we designed four mutants of TBA (ΔT3, ΔT7, ΔT9, ΔT12), in which thymine residues (T3, T7, T9 and T12) were deleted from the loop regions of TBA G-quadruplex. For the mutants the thermodynamics and the...

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Identifiers

PMID: 22851057
DOI: 10.1039/c2mb25234a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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