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Article

Mutational and structural-based analyses of the osmolyte effect on protein stability.

Journal of biochemistry - 1 Jun 2004

Takano Kazufumi, Saito Minoru, Morikawa Masaaki, Kanaya Shigenori

Abstract excerpt

It is known that several naturally occurring substances known as osmolytes increase the conformational stability of proteins. Bolen and co-worker proposed the osmophobic theory, which asserts the osmolyte effect occurs because of an unfavorable interaction of osmolytes mainly with the protein bac...

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Identifiers

PMID: 15213245
DOI: 10.1093/jb/mvh085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15213245-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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