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Article

Mutation of charged residues to neutral ones accelerates urea denaturation of HP-35.

The journal of physical chemistry. B - 16 Sept 2010

Wei Haiyan, Yang Lijiang, Gao Yi Qin

Abstract excerpt

Following the studies of urea denaturation of β-hairpins using molecular dynamics, in this paper, molecular dynamics simulations of two peptides, a 35 residue three helix bundle villin headpiece protein HP-35 and its doubly norleucine-substituent mutant (Lys24Nle/Lys29Nle) HP-35 NleNle, were unde...

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Source

Identifiers

PMID: 20726545
DOI: 10.1021/jp103770y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20726545-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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