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Article

Analysis of a water mediated protein-protein interactions within RNase T1.

Biochemistry - 6 Jun 2000

Langhorst U, Backmann J, Loris R, Steyaert J

Abstract excerpt

Buried and well-ordered solvent molecules are an integral part of each folded protein. For a few individual water molecules, the exchange kinetics with solvent have been described in great detail. So far, little is known about the energetics of this exchange process. Here, we present an experimental approach to investigate water-mediated intramolecular protein-protein interactions by use of double mutant cycles....

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Identifiers

PMID: 10828976
DOI: 10.1021/bi992131m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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