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Article

Positive contribution of hydration structure on the surface of human lysozyme to the conformational stability.

The Journal of biological chemistry - 14 Jun 2002

Funahashi Jun, Takano Kazufumi, Yamagata Yuriko, Yutani Katsuhide

Abstract excerpt

Water molecules make a hydration structure with the network of hydrogen bonds, covering on the surface of proteins. To quantitatively estimate the contribution of the hydration structure to protein stability, a series of hydrophilic mutant human lysozymes (Val to Ser, Tyr, Asp, Asn, and Arg) modified at three different positions on the surface, which are located in the alpha-helix (Val-110), the beta-sheet...

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Source

Identifiers

PMID: 11927576
DOI: 10.1074/jbc.M110728200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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