Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.

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Article

Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.

Journal of experimental & clinical cancer research : CR - 1 Jun 2006

Noda H, Kato Y, Yoshikawa H, Arai M, Togashi K, Nagai H, Konishi F, Miki Y

Abstract excerpt

The development of colorectal neoplasms proceeds mainly via the adenoma-carcinoma sequence. BRAF and RASSF1A are members of Ras-signaling pathways, but the roles of their aberrations in colorectal carcinogenesis remain unclear. The authors studied mutations of the BRAF and K-ras genes, RASSF1A promoter methylation, and p53 overexpression in 43 polypoid-type and 30 flat-type early-stage colorectal cancers. No...

Topics

Adenocarcinoma
Aged
Colorectal Neoplasms
DNA Methylation
DNA Mutational Analysis
Disease Progression
Female
Genes, ras
Humans
Lymph Nodes
Male
Middle Aged
Mutation
Neoplasm Invasiveness

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polyploidy

Promoter Regions, Genetic

Proto-Oncogene Proteins B-raf

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 16918136

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.