Article
CFTR is involved in the fine tuning of intracellular redox status: physiological implications in cystic fibrosis.
The American journal of pathology - 1 Oct 2012
Duranton Christophe, Rubera Isabelle, Cougnon Marc, Melis Nicolas, Chargui Abderrahman, Mograbi Baharia, Tauc Michel
Abstract excerpt
Adaptation to hypoxia is an essential physiological response to decrease in tissue oxygenation. This process is primarily under the control of transcriptional activator hypoxia-inducible factor (HIF1). A better understanding of the intracellular HIF1 stabilization pathway would help in management of various diseases characterized by anemia. Among human pathologies, cystic fibrosis disease is characterized by a...
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