Article

The mitochondrial Na <sup>+</sup> /Ca <sup>2+</sup> exchanger NCLX is implied in the activation of hypoxia-inducible factors

2024-07-12

Abstract excerpt

Eukaryotic cells and organisms depend on oxygen for basic living functions, and they display a panoply of adaptations to situations in which oxygen availability is diminished (hypoxia). A number of these responses in animals are mediated by changes in gene expression programs directed by hypoxia-inducible factors (HIFs), whose main mechanism of stabilization and functional activation in response to decreased cytos...

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Literature Corpus work: dc4743bf-dcdc-5876-99a2-e7841f13c167
DOI: 10.1101/2024.07.12.603081

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