Article
Superoxide dismutase-1 influences the timing and post-hypoxic stability of neonatal breathing.
Advances in experimental medicine and biology - 1 Jan 2008
Cummings Kevin J, Kalf Dan, Moore Sherry, Miller B Joan, Jirik Frank R, Wilson Richard J A
Abstract excerpt
Reactive oxygen species (ROS) likely play a role in the hypoxic ventilatory response. We determined whether hypoxic responses were influenced by alterations in cellular redox status induced by reductions in superoxide dismutase-1 (SOD-1) activity, a cytosolic anti-oxidant enzyme. Using whole-body, continuous-flow plethysmography, we compared ventilatory responses to moderate hypoxia (10% inspired O2) of Sod1+/+,...
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