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Oxidative Stress Regulates <i>CFTR</i> Gene Expression in Human Airway Epithelial Cells through a Distal Antioxidant Response Element

26 Sept 2014

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator gene (CFTR) expression in human airway epithelial cells involves the recruitment of distal cis-regulatory elements, which are associated with airway-selective DNase hypersensitive sites at -44 kb and -35 kb from the gene. The -35-kb site encompasses an enhancer that is regulated by the immune mediators interferon regulatory factor 1 and 2 and by nuclear factor...

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PMID: 25259561
DOI: 10.1165/rcmb.2014-0263oc

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