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Article

[The impact of hypoxia on the ion channels in cystic fibrosis bronchial epithelial cells].

Revue des maladies respiratoires - 1 Mar 2023

Pascarel K, Colas J, Mirval S, Becq F, Vandebrouck C

Abstract excerpt

Cystic fibrosis is a disease caused by a mutation on the CFTR gene coding for a chloride channel. The dominant mutation F508del eliminates the CFTR protein at the surface of epithelial cells, causing an accumulation of viscous mucus in the airways. In advanced stages of the disease, respiratory failure is associated with cellular hypoxia. Our project aims not only to describe the impact of hypoxia on ion channels...

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Source

Identifiers

PMID: 36775781
DOI: 10.1016/j.rmr.2023.01.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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