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Article

Nrf2 expands the intracellular pool of the chaperone AHSP in a cellular model of β-thalassemia

20 Jan 2022

Abstract excerpt

In β-thalassemia, free α-globin chains are unstable and tend to aggregate or degrade, releasing toxic heme, porphyrins and iron, which produce reactive oxygen species (ROS). α-Hemoglobin-stabilizing protein (AHSP) is a potential modifier of β-thalassemia due to its ability to escort free α-globin and inhibit the cellular production of ROS. The influence of AHSP on the redox equilibrium raises the question of...

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PMID: 35092867
DOI: 10.1016/j.redox.2022.102239

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