Article
Point mutations of ras oncogenes are an early event in thyroid tumorigenesis.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 1990
Namba H, Rubin S A, Fagin J A
Abstract excerpt
Identifying the nature of the genetic mutations in thyroid neoplasms and their prevalence in the various tumor phenotypes is critical to understanding their pathogenesis. Mutational activation of ras oncogenes in human tumors occurs predominantly through point mutations in two functional regions of the molecules, codons 12, 13 (GTP-binding domain) or codon 61 (GTPase domain). We examined the prevalence of point...
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