The RET proto-oncogene in medullary and papillary thyroid carcinoma. Molecular features, pathophysiology and clinical implications.

doi:10.1007/s004280050062

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The RET proto-oncogene in medullary and papillary thyroid carcinoma. Molecular features, pathophysiology and clinical implications.

Virchows Archiv : an international journal of pathology - 1 Jul 1997

Komminoth P

Abstract excerpt

The evolution of cancer is a multistep phenomenon, and multiple cellular genetic lesions are involved in the emergence of the malignant neoplasm. Several early events have been implicated in the neoplastic transformation of thyrocytes, and recent reports have described the involvement of specific...

Topics

Carcinoma, Medullary
Carcinoma, Papillary
DNA, Neoplasm
Drosophila Proteins
Gene Expression Regulation, Neoplastic
Genes, ras
Hirschsprung Disease
Humans
Mutation
Neuroendocrine Tumors
Proto-Oncogene Mas
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ret
Proto-Oncogene Proteins p21(ras)
Proto-Oncogenes
Receptor Protein-Tyrosine Kinases
Thyroid Neoplasms
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 9247627
DOI: 10.1007/s004280050062

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9247627-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics