Article
H-ras protooncogene mutations in human thyroid neoplasms.
The Journal of clinical endocrinology and metabolism - 1 Jul 1990
Namba H, Gutman R A, Matsuo K, Alvarez A, Fagin J A
Abstract excerpt
Structural alterations of protooncogene sequences may be involved in the pathogenesis of human neoplasms. We screened 54 thyroid tumors (36 benign and 18 malignant) for gene rearrangements of the protooncogenes c-myc, c-myb, c-fos, c-erb-B1, c-erb-B2, c-erb-A, N-ras, K-ras, and H-ras. Only mutations of H-ras were observed. None of the 15 colloid adenomas examined had detectable H-ras rearrangements. Of the...
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