Molecular defects in thyroid carcinomas: role of the RET oncogene in thyroid neoplastic transformation.

doi:10.1530/eje.0.1330513

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Article

Molecular defects in thyroid carcinomas: role of the RET oncogene in thyroid neoplastic transformation.

European journal of endocrinology - 1 Nov 1995

Santoro M, Grieco M, Melillo R M, Fusco A, Vecchio G

Abstract excerpt

Tumors are believed to arise as a result of an accumulation of mutations in critical genes involved in the control of cell proliferation. Thyroid neoplasms represent a good model for studying the role of these mutations in epithelial cell multistep carcinogenesis because they comprise a broad spe...

Topics

Carcinoma
Carcinoma, Papillary
Cell Transformation, Neoplastic
Drosophila Proteins
Gene Expression Regulation, Neoplastic
Humans
Mutation
Oncogenes
Phenotype
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ret
Receptor Protein-Tyrosine Kinases
Receptor, trkA
Receptors, Nerve Growth Factor
Thyroid Neoplasms
Tumor Suppressor Protein p53

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Open in PubMed

Identifiers

PMID: 7581978
DOI: 10.1530/eje.0.1330513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7581978-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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