Article
Ras oncogene mutations in benign and malignant thyroid neoplasms.
The Journal of clinical endocrinology and metabolism - 1 Oct 1991
Karga H, Lee J K, Vickery A L, Thor A, Gaz R D, Jameson J L
Abstract excerpt
Current models for tumorigenesis propose that a series of genetic alterations occur during the progression from the normal cell to the malignant phenotype. Mutations in each of the three ras genes (K-ras, H-ras, and N-ras) have been identified in many human neoplasms, including thyroid cancer. In this study we examined genomic DNA from benign and malignant thyroid neoplasms for mutations that are known to...
Topics
- Adenocarcinoma
- Adenoma
- Adult
- Aged
- DNA, Neoplasm
- Female
- Genes, ras
- Humans
- Male
- Middle Aged
- Mutation
- Nucleic Acid Hybridization