Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.

The Journal of biological chemistry - 14 Sept 2012

He Jing, Shi Linda Z, Truong Lan N, Lu Chi-Sheng, Razavian Niema, Li Yongjiang, Negrete Alejandro, Shiloach Joseph, Berns Michael W, Wu Xiaohua

Abstract excerpt

The Mre11-Rad50-Nbs1 (MRN) complex plays critical roles in checkpoint activation and double-stranded break (DSB) repair. The Rad50 zinc hook domain mediates zinc-dependent intercomplex associations of MRN, which is important for DNA tethering. Studies in yeast suggest that the Rad50 zinc hook domain is essential for MRN functions, but its role in mammalian cells is not clear. We demonstrated that the human Rad50...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acid Anhydride Hydrolases
Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Separation

Share to Chromosomes

Share to DNA Breaks, Double-Stranded

Share to DNA Repair Enzymes

Share to MRE11 Homologue Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 22833675
DOI: 10.1074/jbc.M112.384750
PMCID: PMC3442509

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.PMID 22833675Read ↗

Interdependence of the rad50 hook and globular domain functions.Semantic proximity Read ↗

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis.Semantic proximity Read ↗

The Rad50 hook domain is a critical determinant of Mre11 complex functions.Semantic proximity Read ↗

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair.Semantic proximity Read ↗

Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairSemantic proximity Read ↗

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.Semantic proximity Read ↗

The MRN complex in double-strand break repair and telomere maintenance.Semantic proximity Read ↗

Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.Semantic proximity Read ↗

Mre11 complex links sister chromatids to promote repair of a collapsed replication fork.Semantic proximity Read ↗

Chromosome fragmentation after induction of a double-strand break is an active process prevented by the RMX repair complex.Semantic proximity Read ↗

Mre11 liberates cGAS from nucleosome sequestration during tumorigenesisSemantic proximity Read ↗

The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.