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Article

The Rad50 hook domain is a critical determinant of Mre11 complex functions.

Nature structural & molecular biology - 1 May 2005

Wiltzius Jed J W, Hohl Marcel, Fleming James C, Petrini John H J

Abstract excerpt

The Mre11 complex (in Saccharomyces cerevisiae: Mre11, Rad50 and Xrs2) influences multiple facets of chromosome break metabolism. A conserved feature of the Mre11 complex is a zinc-coordinating motif in Rad50 called the Rad50 hook. We established a diploid yeast strain, rad50(hook), in which Rad50 is encoded in halves, one from each of the two RAD50 alleles, with the residues constituting the hook deleted. In all...

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Source

Identifiers

PMID: 15852023
DOI: 10.1038/nsmb928

Genes

RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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