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Article

Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia.

Journal of neuroinflammation - 28 Sept 2012

Horiuchi Makoto, Wakayama Kouji, Itoh Aki, Kawai Kumi, Pleasure David, Ozato Keiko, Itoh Takayuki

Abstract excerpt

BACKGROUND: Recent fate-mapping studies establish that microglia, the resident mononuclear phagocytes of the CNS, are distinct in origin from the bone marrow-derived myeloid lineage. Interferon regulatory factor 8 (IRF8, also known as interferon consensus sequence binding protein) plays essential roles in development and function of the bone marrow-derived myeloid lineage. However, little is known about its roles...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23020843
DOI: 10.1186/1742-2094-9-227
PMCID: PMC3546867

Genes

AIF1
CSF1
CSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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