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Article

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

13 May 2014

Abstract excerpt

In response to neuronal injury or disease, microglia adopt distinct reactive phenotypes via the expression of different sets of genes. Spinal microglia expressing the purinergic P2X4 receptor (P2X4R) after peripheral nerve injury (PNI) are implicated in neuropathic pain. Here we show that interferon regulatory factor-5 (IRF5), which is induced in spinal microglia after PNI, is responsible for direct...

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Share to Adenosine and Purinergic Signaling
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PMID: 24818655
DOI: 10.1038/ncomms4771

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