Article

Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injury

2023-06-07

Abstract excerpt

Accumulating evidence suggests that type I interferon (IFN-I) signaling is a key contributor to immune cell-mediated neuropathology in neurodegenerative diseases. Recently, we demonstrated a robust upregulation of type I interferon-stimulated genes in microglia and astrocytes following experimental traumatic brain injury (TBI). The specific molecular and cellular mechanisms by which IFN-I signaling impacts the neu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 768314fe-6ba5-5f7b-b8e1-83cf47fd1f58
DOI: 10.1101/2023.06.06.543774

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injuryDOI 10.1101/2023.06.06.543774Read

Traumatic brain injury results in unique microglial and astrocyte transcriptomes enriched for type I interferon responseSemantic proximity Read

Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain InjurySemantic proximity Read

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficitsSemantic proximity Read

Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortexSemantic proximity Read

Type I interferon pathway in CNS homeostasis and neurological disordersSemantic proximity Read

Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury.Semantic proximity Read

Human Neural Stem Cell Transplantation-Mediated Alteration of Microglial/Macrophage Phenotypes after Traumatic Brain Injury.Semantic proximity Read

Distinct expression profile reveals glia involvement in the trigeminal system attributing to post-traumatic headacheSemantic proximity Read

Controlled Cortical Impact and Craniotomy Induce Strikingly Similar Profiles of Inflammatory Gene Expression, but with Distinct KineticsSemantic proximity Read

IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype.Semantic proximity Read

Interferons, Signal Transduction Pathways, and the Central Nervous SystemSemantic proximity Read

Brain injury contributes to dopaminergic neurodegeneration, Lewy body pathology, and Parkinsonism preclinically with outcomes altered by T cell modulationSemantic proximity Read