Article
Evidence of inbreeding depression on human height.
PLoS genetics - 1 Jan 2012
McQuillan Ruth, Eklund Niina, Pirastu Nicola, Kuningas Maris, McEvoy Brian P, Esko Tõnu, Corre Tanguy, Davies Gail, Kaakinen Marika, Lyytikäinen Leo-Pekka, Kristiansson Kati, Havulinna Aki S, Gögele Martin, Vitart Veronique, Tenesa Albert, Aulchenko Yurii, Hayward Caroline, Johansson Asa, Boban Mladen, Ulivi Sheila, Robino Antonietta, Boraska Vesna, Igl Wilmar, Wild Sarah H, Zgaga Lina, Amin Najaf, Theodoratou Evropi, Polašek Ozren, Girotto Giorgia, Lopez Lorna M, Sala Cinzia, Lahti Jari, Laatikainen Tiina, Prokopenko Inga, Kals Mart, Viikari Jorma, Yang Jian, Pouta Anneli, Estrada Karol, Hofman Albert, Freimer Nelson, Martin Nicholas G, Kähönen Mika, Milani Lili, Heliövaara Markku, Vartiainen Erkki, Räikkönen Katri, Masciullo Corrado, Starr John M, Hicks Andrew A, Esposito Laura, Kolčić Ivana, Farrington Susan M, Oostra Ben, Zemunik Tatijana, Campbell Harry, Kirin Mirna, Pehlic Marina, Faletra Flavio, Porteous David, Pistis Giorgio, Widén Elisabeth, Salomaa Veikko, Koskinen Seppo, Fischer Krista, Lehtimäki Terho, Heath Andrew, McCarthy Mark I, Rivadeneira Fernando, Montgomery Grant W, Tiemeier Henning, Hartikainen Anna-Liisa, Madden Pamela A F, d'Adamo Pio, Hastie Nicholas D, Gyllensten Ulf, Wright Alan F, van Duijn Cornelia M, Dunlop Malcolm, Rudan Igor, Gasparini Paolo, Pramstaller Peter P, Deary Ian J, Toniolo Daniela, Eriksson Johan G, Jula Antti, Raitakari Olli T, Metspalu Andres, Perola Markus, Järvelin Marjo-Riitta, Uitterlinden André, Visscher Peter M, Wilson James F
Abstract excerpt
Stature is a classical and highly heritable complex trait, with 80%-90% of variation explained by genetic factors. In recent years, genome-wide association studies (GWAS) have successfully identified many common additive variants influencing human height; however, little attention has been given to the potential role of recessive genetic effects. Here, we investigated genome-wide recessive effects by an analysis...
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