Article
Population genetic differentiation of height and body mass index across Europe.
Nature genetics - 1 Nov 2015
Robinson Matthew R, Hemani Gibran, Medina-Gomez Carolina, Mezzavilla Massimo, Esko Tonu, Shakhbazov Konstantin, Powell Joseph E, Vinkhuyzen Anna, Berndt Sonja I, Gustafsson Stefan, Justice Anne E, Kahali Bratati, Locke Adam E, Pers Tune H, Vedantam Sailaja, Wood Andrew R, van Rheenen Wouter, Andreassen Ole A, Gasparini Paolo, Metspalu Andres, Berg Leonard H van den, Veldink Jan H, Rivadeneira Fernando, Werge Thomas M, Abecasis Goncalo R, Boomsma Dorret I, Chasman Daniel I, de Geus Eco J C, Frayling Timothy M, Hirschhorn Joel N, Hottenga Jouke Jan, Ingelsson Erik, Loos Ruth J F, Magnusson Patrik K E, Martin Nicholas G, Montgomery Grant W, North Kari E, Pedersen Nancy L, Spector Timothy D, Speliotes Elizabeth K, Goddard Michael E, Yang Jian, Visscher Peter M
Abstract excerpt
Across-nation differences in the mean values for complex traits are common, but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased effect size estimates from 17,500 sibling pairs, we...
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