Article
Normal-mode-analysis-guided investigation of crucial intersubunit contacts in the cAMP-dependent gating in HCN channels.
Biophysical journal - 3 Jul 2012
Marni Farzana, Wu Shengjun, Shah Gaurav M, Xu Xin-ping, Hackett Amber R, Xie Changan, Shrestha Sabisha, Liu Lin, Liu Qinglian, Zhou Lei
Abstract excerpt
Protein structures define a complex network of atomic interactions in three dimensions. Direct visualization of the structure and analysis of the interaction potential energy are not straightforward approaches to pinpoint the atomic contacts that are crucial for protein function. We used the tetr...
Topics
- Allosteric Regulation
- Amino Acid Sequence
- Animals
- Binding Sites
- Cyclic AMP
- Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
- Ion Channel Gating
- Ion Channels
- Mice
- Molecular Dynamics Simulation
- Molecular Sequence Data
- Mutation
- Patch-Clamp Techniques