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Article

The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.

Biophysical journal - 8 Feb 2012

Selvaratnam Rajeevan, VanSchouwen Bryan, Fogolari Federico, Mazhab-Jafari Mohammad T, Das Rahul, Melacini Giuseppe

Abstract excerpt

EPAC is a cAMP-dependent guanine nucleotide exchange factor that serves as a prototypical molecular switch for the regulation of essential cellular processes. Although EPAC activation by cAMP has been extensively investigated, the mechanism of EPAC autoinhibition is still not fully understood. The steric clash between the side chains of two conserved residues, L273 and F300 in EPAC1, has been previously shown to...

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Identifiers

PMID: 22325287
DOI: 10.1016/j.bpj.2011.12.030
PMCID: PMC3274826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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