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Article

Expression of BRAF V600E mutant protein in epithelial ovarian tumors.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Mar 2013

Preusser Matthias, Capper David, Berghoff Anna S, Horvat Reinhard, Wrba Fritz, Schindl Monika, Schoppmann Sebastian F, von Deimling Andreas, Birner Peter

Abstract excerpt

BACKGROUND: Genetic analyses have identified BRAF V600E mutations in a subset of ovarian carcinomas. The aim of this study was to investigate the expression of BRAF V600E aberrant protein using a novel mutation-specific antibody in epithelial ovarian tumors. METHODS: We immunohistochemically analyzed expression of V600E-mutant BRAF protein in archival formalin-fixed, paraffin-embedded tissue specimens of 142...

Topics

Carcinoma
Cystadenocarcinoma, Serous
False Positive Reactions
Female
Gene Expression
Humans
Mutation
Neoplasm Grading
Neoplasm Invasiveness
Neoplasms, Glandular and Epithelial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

Proto-Oncogene Proteins B-raf

Retrospective Studies

Sequence Analysis, DNA

Survival Analysis

Source

Identifiers

PMID: 22820660
DOI: 10.1097/PAI.0b013e31825d7402

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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