Article
Comparative study of BRAF gene mutations in ovarian serous tumors by immunohistochemistry and DNA sequencing.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 1 Jan 2000
Liu Yi-Yao, Wang Qing-Ping, Liu Fang-Fang, Zhu Hui-Ting, He Qi-Zhi
Abstract excerpt
PURPOSE: Somatic mutations in the BRAF gene are common in several types of cancer, especially in ovarian serous cancer (OSC). Normally, the BRAF protein is switched on and off in response to signals that control cell growth and development. METHODS: To investigate the correlation between the mutation of BRAF gene and the expression of BRAF protein in OSC, pyrosequencing was performed to detect the mutation of the...
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