Article
Detection of the BRAF V600E mutation in serous ovarian tumors: a comparative analysis of immunohistochemistry with a mutation-specific monoclonal antibody and allele-specific PCR.
Human pathology - 1 Mar 2013
Bösmüller Hans, Fischer Anna, Pham Deborah L, Fehm Tanja, Capper David, von Deimling Andreas, Bonzheim Irina, Staebler Annette, Fend Falko
Abstract excerpt
Mutations of components of the mitogen-activated protein kinase pathway, mainly BRAF, are common in serous ovarian borderline tumors, whereas high-grade serous ovarian carcinomas rarely show this feature. With the advent of specific kinase inhibitors active against BRAF-mutated cancers, rapid and sensitive detection of the BRAF V600E, by far the most common mutation of this gene, is of great practical relevance....
Topics
- Alleles
- Antibodies, Monoclonal
- Biomarkers, Tumor
- Cystadenocarcinoma, Serous
- DNA, Neoplasm
- Female
- Follow-Up Studies
- Humans
- Immunohistochemistry
- Mutation