Article
Genomic dissection and prioritizing of candidate genes of QTL for regulating spontaneous arthritis on chromosome 1 in mice deficient for interleukin-1 receptor antagonist.
Journal of genetics - 1 Aug 2012
Cao Yanhong, Zhang Jifei, Jiao Yan, Yan Jian, Jiao Feng, Liu Xiaoyun, Williams Robert W, Hasty Karen A, Stuart John M, Gu Weikuan
Abstract excerpt
Rheumatoid arthritis is a heterogeneous disease with clinical and biological polymorphisms. IL-1RN is a protein that binds to interleukin-1 (IL-1) receptors and inhibits the binding of IL-1-alpha and IL-1-beta. IL-1RN levels are elevated in the blood of patients with a variety of infectious, immune, and traumatic conditions. Balb/c mice deficient in IL-1ra (mouse gene of IL-1RN) develop spontaneous autoimmune...
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