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Article

Site specific radioiodination of recombinant hirudin.

Analytical biochemistry - 1 Sept 1990

Tuong A, Maftouh M, Picard C, Gachon M

Abstract excerpt

Recombinant hirudin variant rHV2-Lys47 was radioiodinated using the chloramine-T method. Depending on the reaction pH, the two tyrosine residues, Tyr3 and Tyr63, responded differently to iodination but without change in total iodination yield. Of the incorporated -125 iodine 80% was located on Tyr3 at pH 7.4, but 65% was found on Tyr63 at pH 4. These distinct iodination patterns suggest the existence of a...

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Identifiers

PMID: 2281861
DOI: 10.1016/0003-2697(90)90105-i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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