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Article

Recombinant hirudin: kinetic mechanism for the inhibition of human thrombin.

Protein engineering - 1 Feb 1991

Stone S R, Hofsteenge J

Abstract excerpt

Recombinant hirudin variant-2(Lys47), was found to be a competitive inhibitor of human alpha-thrombin with respect to peptidyl p-nitroanilide substrates. These results contrast with those of Degryse and coworkers that suggest that recombinant hirudin variant-2(Lys47) inhibited thrombin by a noncompetitive mechanism [Degryse et al. (1989) Protein Engng, 2, 459-465]. gamma-Thrombin, which can arise from...

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Source

Identifiers

PMID: 1857714
DOI: 10.1093/protein/4.3.295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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